FDA-Approved Peptides: The Complete 2025 List

Introduction

While many peptides remain research compounds, numerous peptide-based medications have achieved FDA approval after rigorous clinical testing. This guide lists approved peptide drugs by category.

Diabetes and Metabolic

GLP-1 Receptor Agonists

Semaglutide

Brand names: Ozempic, Wegovy, Rybelsus
Approved for: Type 2 diabetes, chronic weight management
Administration: Weekly injection or daily oral

Tirzepatide

Brand names: Mounjaro, Zepbound
Approved for: Type 2 diabetes, chronic weight management
Administration: Weekly injection

Liraglutide

Brand names: Victoza, Saxenda
Approved for: Type 2 diabetes, weight management
Administration: Daily injection

Dulaglutide

Brand name: Trulicity
Approved for: Type 2 diabetes
Administration: Weekly injection

Exenatide

Brand names: Byetta, Bydureon
Approved for: Type 2 diabetes
Administration: Twice daily or weekly injection

Insulin and Related

Insulin (various formulations)

Rapid-acting: Humalog, NovoLog
Long-acting: Lantus, Levemir, Tresiba
Approved for: Diabetes mellitus
Administration: Injection, pump, or inhaled

Glucagon

Brand names: GlucaGen, Baqsimi
Approved for: Severe hypoglycemia
Administration: Injection or nasal spray

Hormonal Conditions

Growth Hormone Related

Tesamorelin

Brand name: Egrifta
Approved for: HIV-associated lipodystrophy
Administration: Daily injection

Macimorelin

Brand name: Macrilen
Approved for: Diagnosis of adult GH deficiency
Administration: Oral (single dose)

Reproductive Hormones

Gonadorelin

Brand name: Factrel
Approved for: Pituitary function testing
Administration: Injection

Leuprolide

Brand names: Lupron, Eligard
Approved for: Prostate cancer, endometriosis, precocious puberty
Administration: Depot injection

Desmopressin

Brand names: DDAVP, Stimate
Approved for: Diabetes insipidus, bedwetting, bleeding disorders
Administration: Nasal, oral, or injection

Other Hormonal

Oxytocin

Brand names: Pitocin, Syntocinon
Approved for: Labor induction, postpartum hemorrhage
Administration: IV or injection

Octreotide

Brand names: Sandostatin
Approved for: Acromegaly, carcinoid tumors
Administration: Injection

Lanreotide

Brand name: Somatuline
Approved for: Acromegaly, neuroendocrine tumors
Administration: Deep subcutaneous injection

Bone Health

Teriparatide

Brand name: Forteo
Approved for: Osteoporosis
Administration: Daily injection (max 2 years)

Abaloparatide

Brand name: Tymlos
Approved for: Postmenopausal osteoporosis
Administration: Daily injection

Calcitonin

Brand names: Miacalcin, Fortical
Approved for: Osteoporosis, Paget's disease
Administration: Nasal spray or injection

Sexual Health

Bremelanotide (PT-141)

Brand name: Vyleesi
Approved for: Hypoactive sexual desire disorder in women
Administration: Subcutaneous injection (as needed)

Gastrointestinal

Linaclotide

Brand name: Linzess
Approved for: IBS-C, chronic constipation
Administration: Oral capsule

Plecanatide

Brand name: Trulance
Approved for: Chronic constipation, IBS-C
Administration: Oral tablet

Cardiovascular

Eptifibatide

Brand name: Integrilin
Approved for: Acute coronary syndrome
Administration: IV infusion

Bivalirudin

Brand name: Angiomax
Approved for: PCI anticoagulation
Administration: IV infusion

Pain Management

Ziconotide

Brand name: Prialt
Approved for: Severe chronic pain
Administration: Intrathecal infusion

HIV/Antiviral

Enfuvirtide

Brand name: Fuzeon
Approved for: HIV infection (salvage therapy)
Administration: Subcutaneous injection

Rare Genetic Conditions

Setmelanotide

Brand name: Imcivree
Approved for: Specific genetic obesity syndromes
Administration: Daily injection

Pegvisomant

Brand name: Somavert
Approved for: Acromegaly
Administration: Daily injection

Diagnostic Agents

Cosyntropin

Brand name: Cortrosyn
Approved for: Adrenal insufficiency diagnosis
Administration: IV or IM injection

Conclusion

FDA-approved peptides span numerous therapeutic categories, from common conditions like diabetes to rare genetic disorders. This approval process ensures extensive safety and efficacy data, distinguishing these medications from research-only peptides.

This list is current as of 2025. New approvals occur regularly. Consult healthcare providers for treatment decisions.