MK-677
Also known as: Ibutamoren, Nutrobal, L-163,191
An orally active growth hormone secretagogue that mimics ghrelin. Not a peptide technically, but frequently discussed alongside GH peptides due to similar effects.
Mechanism of Action
MK-677 binds to ghrelin receptors (GHSR) in the brain, stimulating sustained GH release and increasing IGF-1 levels. Unlike injectable GHRPs, it's orally bioavailable and has a long half-life providing 24-hour GH elevation.
Research Summary
Studies show significant increases in GH and IGF-1 levels, improved sleep quality, and increased lean body mass. Research in elderly shows reversal of diet-induced nitrogen wasting. Long-term studies demonstrate sustained efficacy.
Research Protocols
Note: Doses from research studies
Common Doses
- •10-25 mg daily
- •25 mg most common
Duration
8-12 weeks or longer
Administration
Oral
Side Effects & Considerations
- •Increased appetite
- •Water retention
- •Lethargy initially
- •Numbness/tingling
- •Elevated blood glucose possible
- •Potential prolactin increase
References
Want updates on MK-677 research?
Subscribe to get notified when we add new research findings, protocol updates, and related peptide information.
Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.